Videos of Interleukin-1 in osteoarthritis

Videos of Interleukin-1 in osteoarthritis

IL-1 is a very important cytokine in the early steps of osteoarthritis, giving the high sensitivity of the chondrocytes to this cytokine, and it can be considered the bridge permiting the dialogue between the different structures of the articulation, in such a way that the cartilage is not the only tissue affected in OA.
IL-1 increases the destruction of the extracellular matrix of the cartilage increasing the collagenolytic activity of metalloproteases, increasing activity of nytric oxide ON, wich can induce apoptosis of chondrocytes. Interestingly, IL-1 further induces changes in the homeostasis of the cartilage, lessening activity of growth factors, such as TGF-beta.

Key words: IL-1 – osteoarthritis – MMP – nytric oxide – cartilage homeostasis


Knols on Rheumatology by Alejandro Melo Florián M.D.

The following videos depict the mechanisms of IL-1 in osteoarthritis

Mechanism of action of IL-1 (interleukin 1) in osteoarthritis

IL-1 en OA

 Blockade of IL-1 in OA

Bloqueo de IL-1en OA

Interleukin-1 and Transforming Growth Factor Beta

IL-1 y TGF beta

Collection of knols by Alejandro Melo Florián M.D.



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Alejandro Melo-Florián

Writer, Internal Medicine specialist. Bogotá D.C -Colombia
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Last edited: Aug 26, 2011 10:25 PM.

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