Videos of Interleukin-1 in osteoarthritis
IL-1 is a very important cytokine in the early steps of osteoarthritis, giving the high sensitivity of the chondrocytes to this cytokine, and it can be considered the bridge permiting the dialogue between the different structures of the articulation, in such a way that the cartilage is not the only tissue affected in OA.
IL-1 increases the destruction of the extracellular matrix of the cartilage increasing the collagenolytic activity of metalloproteases, increasing activity of nytric oxide ON, wich can induce apoptosis of chondrocytes. Interestingly, IL-1 further induces changes in the homeostasis of the cartilage, lessening activity of growth factors, such as TGF-beta.
Key words: IL-1 – osteoarthritis – MMP – nytric oxide – cartilage homeostasis
Knols on Rheumatology by Alejandro Melo Florián M.D.
The following videos depict the mechanisms of IL-1 in osteoarthritis