Categoría: Osteartrosis

Citación académica
Referencia # 64 en:
Clinical Science January 2016; 130(9)
Interleukin-1 induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes.
ChienC.-y. HuangC.-h. Tsai et al:
https://alejandromeloflorianmdbio.wordpress.com/2018/08/12/academic-quote/
Sobre artrosis degenerativa – Información miscelánea de interés.
Tomado de original https://osteomuscularnews.wordpress.com/2015/03/21/sobre-artrosis-degenerativa-informacion-miscelanea-de-interes/
La artrosis es una enfermedad de muy lenta evolución en el tiempo, por lo cual se tiende a infravalorar verla desde un punto de vista terapéutico, considerándola principalmente un «síndrome doloroso» para el cual el tratamiento consiste en analgésicos y anti-inflamatorios. Pero lo cierto es que el cartílago hialino es un tejido dinámico, aunque de crecimiento muy lento en el tiempo, lo cual hace que intervenciones clínicas para modificar la evolución de la enfermedad, con los llamados «modificadores estructurales» todavía sean materia de controversia.
Y ahora la concepción de la enfermedad articular degenerativa se ha orientado a falla articular, del mismo modo que ocurre con falla cardíaca o renal, lo cual justifica un manejo más enfocado en el seguimiento y terapia a largo plazo.
El interés de hacer que haya más conciencia sobre esta enfermedad ha motivado publicaciones en diferentes sitios de la web. Más información en los siguientes links:
https://medium.com/@alejandromelo00/cart%C3%ADlago-articular-introducci%C3%B3n-a-morfofisiolog%C3%ADa-17dd8c463c4d
Artículo sobre cartílago hialino en sitio web Medium
http://www.researchgate.net/publication/215744866_Cartlago_articular_introduccin_a_morfofisiologa
Artículo descargable en formato pdf sobre cartílago hialino, en sitio web Research Gate
https://www.academia.edu/7483362/IL-1_y_TGF_Beta_Importancia_en_patog%C3%A9nesis_de_osteoartritis
Exposición del autor sobre interleucina uno y factor transformador de crecimiento tipo beta en osteoartrosis, dictada en Congreso IOCIM en Riviera Maya en Junio de 2014
https://osteomuscularnews.wordpress.com/category/osteoarthritis/
Compilación sobre patologías osteomusculares en sitio web WordPress
http://learni.st/users/1109587/boards/100638-enfermedades-reum-ticas
Compilación sobre enfermedades reumáticas en sitio web Learnist
https://www.academia.edu/898728/TGF-%CE%B2_role_in_osteoarthritis._A_review
El papel del factor transformador de crecimiento tipo beta en osteoartrosis
https://osteomuscularnews.wordpress.com/2014/10/18/generalidades-de-aparato-osteoarticular/
Generalidades de Aparato Osteoarticular
https://www.academia.edu/1740864/Sinovitis_por_IL-1_en_articulaciones_zigapofisiarias_y_utilidad_de_diacere%C3%ADna
Sinovitis en articulaciones zigoapofisiarias de columna y utilidad de diacereína
https://osteomuscularnews.wordpress.com/2011/11/27/9/
Nociones de biología y metabolismo óseo
http://nuevoenmedicina.blogspot.com/2013/12/osteoartrosis-o-enfermedad-articular.html
Explicación sobre la artrosis, para pacientes
http://nuevoenmedicina.blogspot.com/2014/01/artrosis-de-rodilla.html?spref=bl
Información sobre qué es la artrosis de rodilla
http://issuu.com/alejandromeloflorian/docs/a_melo_open_journal_of_medicine_201/1?e=2832809/5356081
Sobre el papel de la interleucina uno en artrosis, publicado en idioma inglés en la revista Open Journal of Medicine
http://www.scoop.it/t/temas-sobre-reumatologia-y-aparato-osteomuscular
Compilación de publicaciones propias y de literatura sobre estos temas de aparato osteoarticular en sitio Web Scoop.it
http://alejandromeloflorian-osteomuscular.blogspot.com/
Información sobre patología osteomuscular en sitio web Blogger
http://issuu.com/alejandromeloflorian/docs/oxaproxin_pla
Novedades terapéuticas con antiinflamatorio oxaprozin
Nota: El contenido de este documento no reemplaza el adecuado consejo del médico tratante.
http://nuevoenmedicina.blogspot.com/2014/01/
Este material sirve para ayudar a explicar determinadas condiciones al paciente, siempre y cuando se haga con la adecuada orientación por parte del médico tratante.
Nociones de biología y metabolismo óseo
Introducción al aparato osteoarticular
Alejandro Melo -Florián MD: Brief Profile
Biblioteca de temas en Osteomuscular
Biblioteca de temas en Osteomuscular

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Recursos en la web
Abstract
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IL-1 and its role in osteoarthritis
IL-1 and its role in osteoarthritis
A new paradigm in physiopathology of a very common osteoarticular disease
Given the high and rising figures of people with osteoarthritis, knowledge of new factors defining course and evolution of the disease are important, when considering new pharmacological targets.
IL-1 is a very important cytokine in the early steps of osteoarthritis, giving the high sensitivity of the chondrocytes to this cytokine, and it can be considered the bridge permiting the dialogue between the different structures of the articulation, in such a way that the cartilage is not the only tissue affected in OA.
IL-1 increases the destruction of the extracellular matrix of the cartilage increasing the collagenolytic activity of metalloproteases, increasing activity of nytric oxide ON, wich can induce apoptosis of chondrocytes. Interestingly, IL-1 further induces changes in the homeostasis of the cartilage, lessening activity of growth factors, such as TGF-beta.
Key words: IL-1 – osteoarthritis – MMP – nytric oxide – cartilage homeostasis
Contents
- Osteoarthritis impact and magnitude
- Osteoarthritis pathophysiology
- Chondrocyte role in cartilage maintenance
- Description of IL-1
- IL-1 and its role in the pathophysiology of osteoarthrtitis
- Ways to demonstrate IL-1 is elevated in OA
- Pharmacological Inhibition of IL-1: usefulness as treatment in OA
- Conclusions

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Osteoarthritis impact and magnitude
The biggest condition causing disability is osteoarthritis, and altogether with joint pain in older people—will be an increasingly important public health concern in the elderly.
Osteoarthritis pathophysiology
Loss of cartilage homeostasis
Synovitis in osteoarthritis
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Superficial synovial cells in synovial membrane
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The synovium produces some of the chemokines and metalloproteinases that degrade cartilage, even though the chondrocytes produces mostly of these destructive molecules. This picture is attributted to the presence of IL-1 in the synoviocites.
Chondrocyte role in cartilage maintenance
Cartilage homeostasis
Description of IL-1
Images by kind courtesy of Tim Manning, http://www.rndsystems.com
IL-1 production
- The synovial membrane. The synthesis of IL-1 is triggered by the resorption of debris cartilage appearing in the articular cavity when there is defragmentation of proteoglycans aggregates. IL-1 present in the synovial fluid penetrates troughout the fissures of fibrilation in cartilage and then reaches the deep layers of the cartilage.
- The bone from areas directly in contact with the calcified cartilage.
- The cartilage because of the mechanical stimulation of chondrocytes.
Levels of IL-1 in OA patients
It has been quantificated by ELISA method, employing murine antibodies to bind directly to IL-1 and rabbit antibodies marked with alkaline phosphatase to bind to the murine antibodies; the levels of Il-1 in OA, were 2,47 pg/mL at day 0, and with administration of diacerhein 100 mg daily the levels down up to 0,28 pg/mL at day 28 (Mathieu 1999).
Nevertheles this figures, there is controversy to correlate high levels with development of OA because there is high sensitivity of the chondrocytes to IL-1 and is known that OA chondrocytes are x4 times more sensitive to deleterious effects of IL-1 when compared to normal chondrocytes.
IL-1 and its role in the pathophysiology of osteoarthrtitis
IL-1 and its effects in chondrocyte
¿Why is IL-1 important in the pathogenesis of osteoarthritis?
ICE enzyme and IL-1 beta production
Nitric oxide and IL-1
Growth factors
Metalloproteases
Ways to demonstrate IL-1 is elevated in OA
Pharmacological Inhibition of IL-1: usefulness as treatment in OA
Conclusions
Youtube video of IL-1
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bluegreenalgae — December 14, 2006 — Interleukin-1 binding to its receptor on a cell surface, created from structural data.
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References.
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Agarwal V, Kumar M, Singh JK, Rathore RK, Misra R, Gupta RK. (2009) Diffusion tensor anisotropy magnetic resonance imaging: a new tool to assess synovial inflammation.Rheumatology (Oxford). 48(4):378-82. Epub 2009 Jan 27.http://www.ncbi.nlm.nih.gov/pubmed/19174567
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Aigner T, Soeder S, Haag J. (2006) IL-1beta and BMPs–interactive players of cartilage matrix degradation and regeneration. Eur Cell Mater; 12:49-56 http://www.ecmjournal.org/journal/papers/vol012/pdf/v012a06.pdf
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Boileau C, Martel-Pelletier J, Moldovan F Jouzeau JY, Netter P, Manning PT Pelletier JP (2002)The In Situ Up-Regulation of Chondrocyte Interleukin-1–Converting Enzyme and Interleukin-18 Levels in Experimental Osteoarthritis Is Mediated by Nitric Oxide. Arthritis & Rheumatism; 46(10): 2637–2647
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Bondeson J, Wainwright SD, Lauder S , Amos N, Hughes E ( 2006 ). The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis.Arthritis Research & Therapy 8:R187 (doi:10.1186/ar2099) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794533/pdf/ar2099.pdf
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de Isla NG & Stoltz JF (2008): In vitro inhibition of IL-1β catabolic effects on cartilage: A mechanism involved on diacerein anti-OA properties. Biorheology 45: 433–43
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Goldring MB & Marcu KB (2009): Cartilage homeostasis in health and rheumatic diseasesArthritis Res & Ther 11:224 (doi:10.1186/ar2592)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714092/pdf/ar2592.pdf
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Jacques C, Gosset M, Berenbaum F, Gabay C (2006). The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation. Vitam Horm. 74: 371-403.
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Krasnokutsky S, Samuels J, Abramson SB (2007). Osteoarthritis in 2007. Bull NYU Hosp Jt Dis. 65(3):222-8. http://www.ncbi.nlm.nih.gov/pubmed/17922674
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Mathieu P. (1999) L´interleukine 1. Son role, son dosage, ses difficulties d´approche dans l´arthrose. Resultats d´un etude pilote avec la diacerheine (ART 50) dans la gonarthrose.Rev Prat (Paris); 49: S15-S18
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Pujol JP (1998): Physiopathologie du cartilage arthrosique Rev Prat (Paris) 46: (Suppl 19) S8-S10
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Studer RK, Jaffurs D, Stefanovic R.M, Robbins P.D. and Evans C.H. (1999) Nitric oxide in osteoarthritis. Osteoarthr Cartilage 7:377–379.
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van der Waal JM, Terwee CB, van der Windt DA. (2005) Health-related and overall quality of life of patients with chronic hip and knee complaints in general practice. Qual Life Res14:795–803 . [CrossRef][Web of Science][Medline]
Complementary Web Resources
Melo-Florián, A: TGF-β role in osteoarthritis. A review [Internet]. Version 18. Open Journal of Medicine. 2011 Sep 8 [revised 2011 Sep 9]. Available from: http://knol.google.com/k/alejandro-melo-florián/tgf-β-role-in-osteoarthritis-a-review/3sktw3ldc86j2/189. http://myopenarchive.org/docs/alejandromelo00/123Melo-Florián A: Osteoarthritis and IL-1: the role of diacerhein as a new therapeutical standard. Medicina de Posgrado 2011; April http://issuu.com/alejandromeloflorian/docs/il1_en_oa_med_posg_2011_aprArtículo de revisión sobre diacereína, un modificador estructural en OA.
Alejandro Melo-Florián
Complementary knol upon cartilage
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Alejandro Melo-Florián
More on osteomuscular conditions
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